Abstract

    We report a patient with chemotherapy refractory Wilms tumor who underwent an unrelated donor cord blood transplant for chemotherapy refractory disease. The preparative regimen consisted of busulfan, melphalan, and anti-thymocyte globulin, and was well tolerated. This patient did not experience significant toxicity related to the chemotherapy regimen and did not develop any graft versus host disease from his HLA (A, B, DR) 6/6 matched cord blood transplant. Follow-up CT scans 2 years post-transplant have shown no evidence of disease progression, with only a few pulmonary nodules remaining, which are unchanged in size from his pre-transplant CT scan. It is possible that high-dose chemotherapy and stem cell transplantation can be curative in patients with tumors that are non-responsive to conventional chemotherapy. 

    我们报告了一名患者进行非亲缘供者脐带血移植治疗难治性化疗耐药肾母细胞瘤的病例，预处理方案白消安、美法仑和抗胸腺细胞球蛋白具有很好的耐受性。此患者没有经历大量的化学疗法所引起的相关毒性，同时也没有发生过移植物抗宿主病（6个位点全相合）。移植后2年后CT检查显示，疾病没有进一步发展，只是部分肺结节在移植前后的大小没有发生变化。大剂量化疗和干细胞移植可以成为对常规化疗不敏感的肿瘤患者的一种合适治疗方法。